Systemic Lupus Erythematosus (SLE)

May 2019- Present

National Institutes of Health

There is a direct correlation between the gene STAT4 and the severity of symptoms for SLE. My team and I successfully created an optimized assay to assess the phosphorylation of STAT4. This has allowed for crucial information, previously inaccessible, to be compiled in future experiments for lupus patients with STAT4 polymorphisms.

Systemic Lupus Erythematosus (SLE): Research

Systemic Lupus Erythematosus (SLE): Image

Systemic Lupus Erythematosus (SLE): Image

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Systemic Lupus Erythematosus (SLE): Image

Conclusions

• We are able to see the phosphorylation of STAT4 with IFN-a and IL-12.
• The phosphorylation of STAT4 by IL-12, requires culturing with a-CD3 and
a-CD28 in order to upregulate the b-2 chain of the IL-12R complex in T
as well as B cells.
• The p-STAT4 assay will be a useful tool to assess functional significance
of the rs7574865 polymorphism in SLE patients.

Systemic Lupus Erythematosus (SLE): Text